Sibutramine

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Sibutramine on Cardiovascular Outcome

S ibutramine, a combined norepinephrine and serotonin reuptake inhibitor, is effective in the management of obese patients requiring pharmacotherapy as part of a multimodal approach to weight loss. It improves insulin resistance markers, glucose metabolism, and atherogenic dyslipidemia in both diabetic and nondiabetic patients, most of these effects resulting fromweight loss. However, sibutrami...

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Phentermine, Sibutramine and Affective Disorders

A safe and effective way to control weight in patients with affective disorders is needed, and phentermine is a possible candidate. We performed a PubMed search of articles pertaining to phentermine, sibutramine, and affective disorders. We compared the studies of phentermine with those of sibutramine. The search yielded a small number of reports. Reports concerning phentermine and affective di...

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Exposure to sibutramine during pregnancy.

QUESTION One of my patients who was taking sibutramine to lose weight found out that she had unexpectedly conceived. The medication was stopped as soon as she found out, about 5 weeks into the pregnancy. Is the baby at risk? Should the pregnancy be aborted? ANSWER No data to date suggest that involuntary exposure to sibutramine during pregnancy carries major risk of congenital malformations. ...

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Cardiovascular Safety Pharmacology of Sibutramine

Sibutramine is an anorectic that has been banned since 2010 due to cardiovascular safety issues. However, counterfeit drugs or slimming products that include sibutramine are still available in the market. It has been reported that illegal sibutramine-contained pharmaceutical products induce cardiovascular crisis. However, the mechanism underlying sibutramine-induced cardiovascular adverse effec...

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Effect of sibutramine on intraocular pressure

Objective This study evaluated the effects of sibutramine on intraocular pressure (IOP) and body-mass index (BMI). Methods Thirty obese females (body-mass index >30 kg/m2) treated with sibutramine (10 mg/day) plus diet restriction for 3 months were included in the study. IOP, BMI, and blood biochemical parameters were measured at the beginning and end of the treatment. Results were evaluated st...

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ژورنال

عنوان ژورنال: Reactions Weekly

سال: 2021

ISSN: ['1179-2051', '0114-9954']

DOI: https://doi.org/10.1007/s40278-021-95297-x